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Literature summary for 2.3.1.67 extracted from
- The sensitivity of bovine corneal epithelial lyso-PAF acetyltransferase to cyclooxygenase and lipoxygenase inhibitors is independent of arachidonate metabolites (1997), J. Ocul. Pharmacol. Ther., 13, 415-426.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-salicylic acid | IC50: 1.52 mM | Bos taurus |  |
| ascorbic acid | 18.3% inhibition at 1 mM | Bos taurus | |
| baicalein | concentration dependent inhibition, IC50: 0.105 mM | Bos taurus | |
| ebselen | suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 7.7% and 26.6% in presence of glutathione | Bos taurus | |
| EDTA | 67.9 and 72.7% inhibition at 0.5 and 1 mM respectively | Bos taurus | |
| Fe2+ | 31% inhibition at 0.01 mM | Bos taurus | |
| gallic acid | 5.3% inhibition at 0.1 mM | Bos taurus | |
| glutathione | suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 18.9% | Bos taurus | |
| H2O2 | 8% inhibition at 1 mM | Bos taurus | |
| indomethacin | IC50: 0.26 mM | Bos taurus | |
| myricetin | suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 17% | Bos taurus | |
| nordihydroguaiaretic acid | concentration dependent inhibition, IC50: 0.075 mM | Bos taurus | |
| quercetin | suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 8.8% | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corneal epithelium | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + alkyl-sn-glycero-3-phosphocholine | - |
Bos taurus | CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
assay at | Bos taurus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.075 | - |
concentration dependent inhibition, IC50: 0.075 mM | Bos taurus | nordihydroguaiaretic acid | |
| 0.105 | - |
concentration dependent inhibition, IC50: 0.105 mM | Bos taurus | baicalein | |
| 0.26 | - |
IC50: 0.26 mM | Bos taurus | indomethacin | |
| 1.52 | - |
IC50: 1.52 mM | Bos taurus | acetyl-salicylic acid | |
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