Literature summary for 2.3.1.67 extracted from

Yamazaki, R.; Sugatani, J.; Fujii, I.; Kuroyanagi, M.; Umehara, K.; Ueno, A.; Suzuki, Y.; Miwa, M.
Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex (1994), Biochem. Pharmacol., 47, 995-1006.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acetyl-salicylic acid	weak inhibition	Rattus norvegicus
baicalein	IC50: 0.148 mM	Rattus norvegicus
chiyusaponin	IC50: 0.2 mM	Rattus norvegicus
honokiol	IC50: 0.06 mM, reversible inhibition	Homo sapiens
honokiol	IC50: 0.15 mM	Rattus norvegicus
indomethacin	weak inhibition at 1 mM	Rattus norvegicus
magnolol	IC50: 0.07 mM, reversible inhibition	Homo sapiens
magnolol	IC50: 0.15 mM	Rattus norvegicus
nordihydroguaiaretic acid	IC50: 0.06 mM	Homo sapiens
nordihydroguaiaretic acid	IC50: 0.29 mM	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + hexadecyl-lyso-sn-glycero-3-phosphocholine	-	Homo sapiens	CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens
37	-	assay at	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.06	-	IC50: 0.06 mM	Homo sapiens	nordihydroguaiaretic acid
0.06	-	IC50: 0.06 mM, reversible inhibition	Homo sapiens	honokiol
0.07	-	IC50: 0.07 mM, reversible inhibition	Homo sapiens	magnolol
0.148	-	IC50: 0.148 mM	Rattus norvegicus	baicalein
0.15	-	IC50: 0.15 mM	Rattus norvegicus	honokiol
0.15	-	IC50: 0.15 mM	Rattus norvegicus	magnolol
0.2	-	IC50: 0.2 mM	Rattus norvegicus	chiyusaponin
0.29	-	IC50: 0.29 mM	Rattus norvegicus	nordihydroguaiaretic acid

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Release 2023.1 (January 2023)