BRENDA - Enzyme Database
show all sequences of 2.3.1.67

Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: Differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors

Roy Baker, R.; Chang, H.y.; Biochim. Biophys. Acta 1390, 215-224 (1998)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
1-acyl-sn-glycero-3-phosphate
competitive inhibition for 1-alkyl-sn-glycero-3-phosphate
Oryctolagus cuniculus
oleic acid
1-acyl lysolipids less inhibited than the 1-alkyl species
Oryctolagus cuniculus
oleoyl-CoA
45-55% inhibition
Oryctolagus cuniculus
serine/threonine phosphatase
diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine
Oryctolagus cuniculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.009
-
1-alkyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
0.011
-
1-acyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
0.018
-
1-alkyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Oryctolagus cuniculus
5634
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-acyl-sn-glycero-3-phosphate
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate
-
487384
Oryctolagus cuniculus
?
acetyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
-
-
-
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.4
-
assay at
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-acyl-sn-glycero-3-phosphate
competitive inhibition for 1-alkyl-sn-glycero-3-phosphate
Oryctolagus cuniculus
oleic acid
1-acyl lysolipids less inhibited than the 1-alkyl species
Oryctolagus cuniculus
oleoyl-CoA
45-55% inhibition
Oryctolagus cuniculus
serine/threonine phosphatase
diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine
Oryctolagus cuniculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.009
-
1-alkyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
0.011
-
1-acyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
0.018
-
1-alkyl-sn-glycero-3-phosphocholine
-
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Oryctolagus cuniculus
5634
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-acyl-sn-glycero-3-phosphate
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate
-
487384
Oryctolagus cuniculus
?
acetyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
?
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
-
-
-
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
487384
Oryctolagus cuniculus
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Oryctolagus cuniculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.4
-
assay at
Oryctolagus cuniculus
Other publictions for EC 2.3.1.67
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736060
Detopoulou
The relation of diet with PAF ...
Homo sapiens
Eur. J. Nutr.
54
25-34
2015
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
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-
1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737183
Vlachogianni
Platelet activating factor (PA ...
Homo sapiens
Prostaglandins Other Lipid Mediat.
121
176-183
2015
1
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736450
Morimoto
Rapid production of platelet-a ...
Mus musculus, Mus musculus C57/BL6J
J. Biol. Chem.
289
15566-15576
2014
1
-
1
-
-
-
-
-
-
1
-
4
-
3
-
1
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
1
-
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-
1
-
1
1
-
-
-
-
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
736604
Tarui
Selective inhibitors of a PAF ...
Homo sapiens, Mus musculus
J. Lipid Res.
55
1386-1396
2014
-
4
2
-
-
-
26
-
1
-
-
2
-
3
-
-
-
-
-
2
-
-
4
-
2
-
-
-
2
-
-
2
-
-
12
-
4
2
2
-
-
-
12
26
-
-
1
-
-
2
-
-
-
-
-
2
-
-
4
-
2
-
-
-
2
-
-
-
2
6
6
2
-
-
735644
Yamazaki
A Penicillium sp. F33 metaboli ...
Mus musculus, Rattus norvegicus
Biochem. Pharmacol.
86
632-644
2013
-
1
1
-
-
-
20
-
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
18
-
1
1
-
-
-
-
18
22
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
3
1
1
3
-
-
736050
Ntzouvani
-
Effect of fortified milk on ly ...
Homo sapiens
Eur. J. Lipid Sci. Technol.
115
142-152
2013
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703250
Detopoulou
Platelet activating factor (PA ...
Homo sapiens
Clin. Biochem.
42
44-49
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
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-
-
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-
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
688161
Kihara
Platelet-activating factor pro ...
Mus musculus
J. Immunol.
181
5008-5014
2008
-
1
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
1
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
701601
Tsoupras
Anti-platelet-activating facto ...
Homo sapiens
AIDS Res. Hum. Retroviruses
24
1079-1086
2008
-
1
-
-
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
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1
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-
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1
-
1
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-
-
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2
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-
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1
-
-
-
-
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3
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
702406
Egea
Increased production of the et ...
Homo sapiens
Biochim. Biophys. Acta
1781
270-276
2008
3
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
704418
Harayama
Identification of a novel noni ...
Mus musculus
J. Biol. Chem.
283
11097-11106
2008
-
-
1
-
10
-
2
2
1
-
1
1
-
3
-
-
1
-
-
3
3
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
10
-
-
2
-
2
1
-
1
1
-
-
-
1
-
3
3
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
672495
Tosaki
Enhancement of acetyl-CoA: 1-O ...
Homo sapiens
Biol. Pharm. Bull.
30
272-278
2007
3
-
-
-
-
-
3
-
-
-
-
1
-
2
-
-
-
-
-
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
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3
-
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-
-
1
-
-
-
-
-
2
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
674893
Shindou
A single enzyme catalyzes both ...
Homo sapiens, Mus musculus
J. Biol. Chem.
282
6532-6539
2007
-
-
2
-
-
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
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2
-
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-
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2
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2
-
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-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659628
Shindou
Priming effect of lipopolysacc ...
Mus musculus
J. Immunol.
175
1177-1183
2005
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672336
Owen
Stress-induced platelet-activa ...
Homo sapiens
Biochim. Biophys. Acta
1733
120-129
2005
-
-
-
-
-
-
-
-
-
-
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1
-
2
-
-
-
-
-
1
-
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1
-
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1
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1
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1
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-
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-
-
-
-
-
675778
Fragopoulou
Characterization of acetyl-CoA ...
Homo sapiens
Mediators Inflamm.
2005
263-272
2005
1
-
-
-
-
-
4
2
-
-
-
-
-
1
-
-
1
-
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2
-
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1
-
1
-
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1
1
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1
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4
-
2
-
-
-
-
-
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-
1
-
2
-
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
658920
Sugatani
Tea polyphenols inhibit acetyl ...
Oryctolagus cuniculus
Int. Arch. Allergy Immunol.
134
17-28
2004
-
-
-
-
-
-
15
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
14
-
-
-
-
-
-
-
14
15
-
-
-
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657735
Corl
Oxidant stress enhances Lyso-P ...
Bos taurus
Biochem. Biophys. Res. Commun.
302
610-614
2003
-
-
-
-
-
-
-
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1
-
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2
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2
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1
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2
-
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-
-
-
-
-
-
-
-
-
658623
Nomikos
Acetyl-CoA:1-O-alkyl-sn-glycer ...
Homo sapiens
Eur. J. Biochem.
270
2992-3000
2003
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
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-
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-
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-
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-
-
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1
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1
-
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
487389
Nagumo
Inhibition of lysoPAF acetyltr ...
Rattus norvegicus
Biol. Pharm. Bull.
22
1144-1146
1999
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
487384
Roy Baker
Substrate specificities of neu ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1390
215-224
1998
-
-
-
-
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487383
Kume
Microplate chromatography assa ...
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1997
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487387
Svetlov
Regulation of platelet-activat ...
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1997
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4
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487390
Hurst
The sensitivity of bovine corn ...
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1997
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13
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487388
Yanoshita
Inhibition of lysoPAF acetyltr ...
Rattus norvegicus
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546-549
1996
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1
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1
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487393
Baker
Alkylglycerophosphate acetyltr ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1302
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1996
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1
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1
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Kudolo
Differential metabolism of exo ...
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315-324
1995
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1
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487385
Yamazaki
Development of a novel method ...
Homo sapiens, Rattus norvegicus
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995-1006
1994
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Garcia
Biosynthesis of platelet-activ ...
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1
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487392
Ihara
Hormonal regulation of platele ...
Rattus norvegicus
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304
503-507
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2
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487375
Lee
1-Alkyl-2-lyso-sn-glycero-3-ph ...
Homo sapiens
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396-401
1992
2
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9
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487381
Ninio
Biosynthesis of paf-acether. X ...
Homo sapiens
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963
288-294
1988
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Lee
A new de novo pathway for the ...
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487376
Gomez-Cambronero
Partial purification and chara ...
Canis lupus familiaris, Rattus norvegicus
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1986
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Lee
Biosynthesis of platelet activ ...
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487380
Gomez-Cambronero
Modulation of lyso-platelet ac ...
Rattus norvegicus
Biochim. Biophys. Acta
845
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1985
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Gomez-Cambronero
Modulation of lyso-platelet-ac ...
Rattus norvegicus
Biochim. Biophys. Acta
845
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1985
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Wykle
Enzymatic synthesis of 1-alkyl ...
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255
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1980
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