Any feedback?
Literature summary for 2.3.1.67 extracted from
- Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid (1980), J. Biol. Chem., 255, 10256-10260.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | 15% inhibition | Rattus norvegicus |  |
| diisopropylfluorophosphate | 98% inhibition at 10 mM | Rattus norvegicus | |
| EGTA | - |
Rattus norvegicus | |
| MgCl2 | 98% inhibition | Rattus norvegicus | |
| MnCl2 | 50% inhibition | Rattus norvegicus | |
| p-bromophenacyl bromide | 90% inhibition at 0.1 mM | Rattus norvegicus | |
| palmitoyl-CoA | 85% inhibition at 10 uM due to detergent effect | Rattus norvegicus | |
| Triton X-100 | 75 and 95% inhibition at 0.2 and 0.6 mM respectively due to detergent | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.067 | - |
acetyl-CoA | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| lymph node | - |
Rattus norvegicus | - |
| renal cortex | - |
Rattus norvegicus | - |
| renal medulla | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
| thymus | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0002 | - |
liver | Rattus norvegicus |
| 0.0002 | - |
kidney cortex | Rattus norvegicus |
| 0.002 | - |
kidney medulla | Rattus norvegicus |
| 0.0026 | - |
bone marrow | Rattus norvegicus |
| 0.0039 | - |
lymph nodes | Rattus norvegicus |
| 0.004 | - |
thymus | Rattus norvegicus |
| 0.004 | - |
lung | Rattus norvegicus |
| 0.01 | - |
spleen microsome | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine | rate of synthesis is 55% of the rate observed with the ether linked substrate | Rattus norvegicus | CoA + 2-acetyl-1-palmitoyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + acyl-lyso-glycero-3-phosphocholine | worse substrate than alkyl-lyso-glycero-3-phosphocholine | Rattus norvegicus | CoA + acetyl-acyl-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + alkyl-sn-glycero-3-phosphocholine | - |
Rattus norvegicus | CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
assay at | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
