Literature summary for 2.3.1.6 extracted from

Cox, M.; Duncan, G.; Lin, G.; Steinberg, B.; Yu, L.; Brenner, D.; Buckler, L.; Elia, A.; Wakeham, A.; Nieman, B.; Dominguez-Brauer, C.; Elford, A.; Gill, K.; Kubli, S.; Haight, J.; Berger, T.; Ohashi, P.; Tracey, K.; Olofsson, P.; Mak, T.
Choline acetyltransferase expressing T cells are required to control chronic viral infection (2019), Science, 363, 639-644 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q03059	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-lymphocyte	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	choline acetyltransferase is robustly induced in both CD4+ and CD8+ T cells during lymphocytic choriomeningitis virus infection in an IL-21-dependent manner. Deletion of ChAT within the T cell compartment in mice ablates vasodilation in response to infection, impairs the migration of antiviral T cells into infected tissues, and ultimately compromises the control of chronic lymphocytic choriomeningitis virus clone 13 infection	Mus musculus

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Release 2023.1 (January 2023)