Literature summary for 2.3.1.6 extracted from

Winick-Ng, W.; Caetano, F.A.; Winick-Ng, J.; Morey, T.M.; Heit, B.; Rylett, R.J.
82-kDa choline acetyltransferase and SATB1 localize to beta-amyloid induced matrix attachment regions (2016), Sci. Rep., 6, 23914 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	nuclei of cholinergic neurons	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28329	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 82000, calculated from sequence	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	acute exposure to amyloid Abeta1-42 results in increased association of ChAT with chromatin and formation of ChAT aggregates in nuclei. Abeta1-42 -exposure increases ChAT association with gene promoters and introns. The Abeta1-42 -induced ChAT aggregates colocalize with special AT-rich binding protein 1 (SATB1), which anchors DNA to scaffolding/matrix attachment regions (S/MARs). Both ChAT and SATB proteins associate with synapse and cell stress genes. After Abeta1-42 -exposure, both SATB1 and ChAT are enriched at the same S/MAR on the APP gene, with ChAT expression attenuating an increase in an isoform-specific APP mRNA transcript	Homo sapiens

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Release 2023.1 (January 2023)