Literature summary for 2.3.1.6 extracted from

Joshi, S.; Virdi, S.; Etard, C.; Geisler, R.; Straehle, U.
Mutation of a serine near the catalytic site of the choline acetyltransferase a gene almost completely abolishes motility of the zebrafish embryo (2018), PLoS ONE, 13, e0207747 .

Search for more literature for 2.3.1.6

Cloned(Commentary)

Cloned (Comment)	Organism
-	Danio rerio

Protein Variants

Protein Variants	Comment	Organism
S102R	mutation in the catalytic domain and in the vicinity of the active site of the enzyme. The change affects protein structure and has a direct impact on the catalytic domain of the protein which abolishes embryo motility almost completely. Mutant fish display reduced embryonic motility from 24 hours post-fertilization onwards. The heart beats at normal rate at 48 hours post-fertilization but decreases over time and ceases around 5 days post-fertilization, resulting in death. The swim bladder fails to inflate. Heterozygotes do not exhibit any mobility or other obvious defects and become healthy adults	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	B2ZGJ1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)