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Literature summary for 2.3.1.6 extracted from

  • Profita, M.; Bonanno, A.; Siena, L.; Bruno, A.; Ferraro, M.; Montalbano, A.M.; Albano, G.D.; Riccobono, L.; Casarosa, P.; Pieper, M.P.; Gjomarkaj, M.
    Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease (2009), J. Pharmacol. Exp. Ther., 329, 753-763.
    View publication on PubMed
Search for more literature for 2.3.1.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + choline Homo sapiens
-
 CoA + O-acetylcholine acetylcholine is the primary parasympathetic neurotransmitter in the airways ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast lung, fetal lung fibroblasts, HFL-1 Homo sapiens
-
HFL-1 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + choline
-
 Homo sapiens CoA + O-acetylcholine
-
 ?
acetyl-CoA + choline
-
 Homo sapiens CoA + O-acetylcholine acetylcholine is the primary parasympathetic neurotransmitter in the airways ?

Synonyms

Synonyms Comment Organism
ChAT
-
 Homo sapiens
choline acetyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-1beta induces the enzyme in HFL-1 cells up

General Information

General Information Comment Organism
malfunction in cigarette smokers and patients with chronic obstructive pulmonary disease, acetylcholine activation in lung fibroblasts causes increased cell proliferation involving muscarinic M1, M2, and M3 receptors, and ERK1/2 and NFkappaB pathways, overview Homo sapiens
physiological function acetylcholine, synthesized by ChAT, and muscarinic M1, M2, and M3 receptors are involved in fibroblast proliferation Homo sapiens