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Literature summary for 2.3.1.6 extracted from

  • Nunes-Tavares, N.; Valverde, R.H.; Araujo, G.M.; Hasson-Voloch, A.
    Toxicity induced by Hg2+ on choline acetyltransferase activity from E. electricus (L.) electrocytes: the protective effect of 2,3 dimercapto-propanol (BAL) (2005), Med. Sci. Monit., 11, BR100-105.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ noncompetitive with respect to choline, IC50: 0.0004 mM, mixed type inhibition with respect to acetyl-CoA, IC50: 0.0025 mM, activity can be recovered using 2,3-dimercapto-propanol Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + choline Electrophorus electricus synthesis of the neurotransmitter acetylcholine acetylcholine + CoA
-
r

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
electric organ
-
Electrophorus electricus
-
electrocyte
-
Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + choline
-
Electrophorus electricus acetylcholine + CoA
-
r
acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine Electrophorus electricus acetylcholine + CoA
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0005
-
Hg2+ pH 7.4, 37°C Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
noncompetitive with respect to choline, IC50: 0.0004 mM, mixed type inhibition with respect to acetyl-CoA, IC50: 0.0025 mM, activity can be recovered using 2,3-dimercapto-propanol Electrophorus electricus Hg2+