Literature summary for 2.3.1.6 extracted from

Sigle, J.P.; Zander, J.; Ehret, A.; Honegger, J.; Jackisch, R.; Feuerstein, T.J.
High potassium-induced activation of choline-acetyltransferase in human neocortex: implications and species differences (2003), Brain Res. Bull., 60, 255-262.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bromo-acetylcholine	-	Homo sapiens
bromo-acetylcholine	-	Mus musculus
ocadaic acid	-	Homo sapiens
ocadaic acid	-	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	highest activity at 10-20 mM K+	Homo sapiens
additional information	addition of K+ does not affect activity	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + choline	Mus musculus	synthesis of the neurotransmitter acetylcholine	acetylcholine + CoA	-	r
acetyl-CoA + choline	Homo sapiens	synthesis of the neurotransmitter acetylcholine	acetylcholine + CoA	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	B6 CBA wild type mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neocortex	-	Mus musculus	-
neocortex	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + choline	-	Mus musculus	acetylcholine + CoA	-	r
acetyl-CoA + choline	-	Homo sapiens	acetylcholine + CoA	-	r
acetyl-CoA + choline	synthesis of the neurotransmitter acetylcholine	Mus musculus	acetylcholine + CoA	-	r
acetyl-CoA + choline	synthesis of the neurotransmitter acetylcholine	Homo sapiens	acetylcholine + CoA	-	r

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Release 2023.1 (January 2023)