Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a veritable therapeutic target in glioblastoma that controls tumor cell stemness and aggressiveness. The enzyme promotes resistance to radiotherapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in U-87MG cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | Homo sapiens | - |
CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | Homo sapiens | - |
CoA + N1-acetylspermine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | - |
Homo sapiens | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | - |
Homo sapiens | CoA + N1-acetylspermine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SAT1 | - |
Homo sapiens |
spermidine/spermine N1-acetyltransferase 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme expression is elevated in aggressive brain tumors | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme regulates the genes MELK and EZH2 by direct interaction with chromatin | Homo sapiens |