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Literature summary for 2.3.1.57 extracted from

  • Thakur, V.S.; Aguila, B.; Brett-Morris, A.; Creighton, C.J.; Welford, S.M.
    Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness (2019), Oncogene, 38, 6794-6800 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.57

Application

Application Comment Organism
medicine the enzyme is a veritable therapeutic target in glioblastoma that controls tumor cell stemness and aggressiveness. The enzyme promotes resistance to radiotherapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in U-87MG cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

Synonyms Comment Organism
SAT1
-
 Homo sapiens
spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme expression is elevated in aggressive brain tumors up

General Information

General Information Comment Organism
physiological function the enzyme regulates the genes MELK and EZH2 by direct interaction with chromatin Homo sapiens