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Literature summary for 2.3.1.57 extracted from

  • Pirnes-Karhu, S.; Maeaettae, J.; Finnilae, M.; Alhonen, L.; Uimari, A.
    Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype (2015), Transgenic Res., 24, 253-265.
    View publication on PubMed
Search for more literature for 2.3.1.57

Cloned(Commentary)

Cloned (Comment) Organism
recombinant overexpression of the enzyme in enzyme-deficient and wild-type mice using the endogenous enzyme promoter, quantitative PCR expression analysis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P48026
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-
Mus musculus C57BL/6JOlaHsd P48026
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-

Source Tissue

Source Tissue Comment Organism Textmining
mesenchymal stromal cell
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 Mus musculus
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osteoblast
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 Mus musculus
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Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
-
 Mus musculus
SSAT
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 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus induction of enzyme SSAT with alpha-methylspermidine disturbs wild-type osteoblastogenesis up

General Information

General Information Comment Organism
malfunction body weights, femur and tibia lengths and diameters, and ash weights of tibia of wild-type, SSAT overexpressing, and SSAT deficient female mice, overview. Enzyme overexpressing SSAT mice have an altered skeletal appearance with increased collagen cleavage and reduced bone strength compared to the wild-type. Engineered mice also show altered differentiation of mesenchymal stromal cells to osteoblasts. Polyamine metabolism of SSAT osteoblasts is disturbed. Osteoblasts of SSAT overexpressing mice show significantly increased SSAT enzyme activity Mus musculus
physiological function spermidine/spermine N1-acetyltransferase is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Role of polyamine metabolism in bone remodeling Mus musculus