Protein Variants | Comment | Organism |
---|---|---|
additional information | small interfering RNAs (siRNAs) against SSAT-1 are transfected weekly in rheumatoid arthritis synovial fibroblasts | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diminazene aceturate | inhibitor of SSAT-1, does not induce apoptosis | Homo sapiens | |
Pentamidine | induces apoptosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme transforms polyamines into putrescine | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21673 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | synovial fibroblasts from patients with rheumatoid arthritis or osteoarthritis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme transforms polyamines into putrescine | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Homo sapiens |
spermidine/spermine N1-acetyltransferase 1 | - |
Homo sapiens |
SSAT-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition also inhibits ongoing joint destruction. Enzyme inhibition or gene silencing by transfection of siRNA targeting SSAT-1 increases 5-methylcytosine levels/PMF-1 promoter methylation within 21 days | Homo sapiens |