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Literature summary for 2.3.1.57 extracted from

  • Simonian, A.; Khomutov, A.; Hyvonen, T.; Grigorenko, N.; Keinanen, T.; Vepsalainen, J.; Alhonen, L.; Janne, J.
    Novel CoA-polyamine conjugates for effective inhibition of spermine/spermidine-N1-acetyltransferase (2007), Nucleosides Nucleotides Nucleic Acids, 26, 1245-1248.
    View publication on PubMed
Search for more literature for 2.3.1.57

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Homo sapiens
-
 CoA + N1-acetylspermine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P21673
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 structure of polyamine fragment of the conjugate important for enzyme activity, existence of adenosine groups crucial for effective inhibition, since conjugates of D-N-pantothenylamidoethyl mercaptane family reveals low inhibitory activities, most exact mimic of the intermediate of N1-acetyltransferase reaction less active than analogue of the intermediate of N8-acetyltransferase reaction, significant contribution of the polyamine fragment into inhibition proven by lower activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermidine mimics of transition state of SSAT1 reaction analyzed Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
acetyl-CoA + spermine mimics of transition state of SSAT1 reaction analyzed Homo sapiens CoA + N1-acetylspermine
-
 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase 1
-
 Homo sapiens
SSAT1
-
 Homo sapiens