Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction | Cricetulus griseus | |
additional information | certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6,6-difluorospermidine | weak inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cricetulus griseus | first enzyme in polyamine catabolism | ? | - |
? | |
additional information | Homo sapiens | first enzyme in polyamine catabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | lung-cancer derived cells | Homo sapiens | - |
CHO cell | - |
Cricetulus griseus | - |
melanoma cell line | melanoma-derived cells C8146C | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 6,6-difluorospermidine | 16.6% of the rate with spermidine | Homo sapiens | CoA + N1-acetyl-6,6-difluorospermidine | - |
? | |
acetyl-CoA + 7,7-difluorospermidine | 19.7% of the rate with spermidine | Homo sapiens | CoA + N1-acetyl-7,7-difluorospermidine | - |
? | |
acetyl-CoA + spermidine | - |
Cricetulus griseus | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermidine | - |
Homo sapiens | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | - |
Cricetulus griseus | CoA + N1-acetylspermine | - |
? | |
acetyl-CoA + spermine | - |
Homo sapiens | CoA + N1-acetylspermine | - |
? | |
additional information | first enzyme in polyamine catabolism | Cricetulus griseus | ? | - |
? | |
additional information | first enzyme in polyamine catabolism | Homo sapiens | ? | - |
? |