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Literature summary for 2.3.1.57 extracted from

  • Ignatenko, N.A.; Fish, J.L.; Shassetz, L.R.; Woolridge, D.P.; Gerner, E.W.
    Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli (1996), Biochem. J., 319, 435-440.
No PubMed abstract available
Search for more literature for 2.3.1.57

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme is induced by isopropyl beta-D-thiogalactopyranoside Homo sapiens

Application

Application Comment Organism
medicine the ability of polyamine analogues to induce N1SSAT activity correlates with the ability to inhibit growth and viability of human tumor-derived cells Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloning and conditional expression of cDNA encoding enzyme in Escherichia coli CAG2242 results in a decrease of endogenous spermidine contents and growth rates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens spermidine acetylation might be a strategy for inhibiting growth in response to environmental stresses CoA + N1-acetylspermidine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant enzyme, expressed in Escherichia coli CAG2242
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine product is exclusively N1-acetylspermidine ?
acetyl-CoA + spermidine spermidine acetylation might be a strategy for inhibiting growth in response to environmental stresses Homo sapiens CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?