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Literature summary for 2.3.1.57 extracted from

  • Wittich, R.M.; Walter, R.D.
    A novel type of putrescine (diamine)-acetylating enzyme from the nematode Ascaris suum (1989), Biochem. J., 260, 265-269.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
PMSF and Brij 35 are essential to prevent rapid loss of activity of the enzyme preparation Ascaris suum

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by CoA Ascaris suum
N-acetylputrescine slight, competitive inhibition Ascaris suum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0077
-
acetyl-CoA
-
Ascaris suum
0.25
-
putrescine
-
Ascaris suum
0.4
-
1,6-diaminohexane
-
Ascaris suum
1.25
-
1,3-diaminopropane
-
Ascaris suum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Ascaris suum 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13000
-
x * ? + x * 13000, catalytic subunit, at least 2 subunits, gel filtration of enzyme precipitated by (NH4)2SO4 Ascaris suum
38000 40000 gel filtration Ascaris suum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ascaris suum important function in the degradation of diamines of lower eukaryotes ?
-
?

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
female adults
-

Purification (Commentary)

Purification (Comment) Organism
1027fold Ascaris suum
partial Ascaris suum

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
Ascaris suum
-
uterus
-
Ascaris suum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.4314
-
-
Ascaris suum

Storage Stability

Storage Stability Organism
-22°C, per month, 10-16% loss of activity Ascaris suum
4°C, per day, 5-9% loss of activity Ascaris suum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 1,3-diaminopropane
-
Ascaris suum CoA + N1-acetyl-1,3-diaminopropane
-
ir
acetyl-CoA + 1,5-diaminopentane cadaverine Ascaris suum CoA + N1-acetyl-1,5-diaminopentane
-
ir
acetyl-CoA + 1,6-diaminohexane
-
Ascaris suum CoA + N1-acetyl-1,6-diaminohexane
-
ir
acetyl-CoA + putrescine
-
Ascaris suum CoA + N-acetylputrescine
-
?
acetyl-CoA + putrescine
-
Ascaris suum CoA + N-acetylputrescine
-
ir
acetyl-CoA + spermidine very poor substrate, at 2-4% of the rate with putrescine Ascaris suum CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine very poor substrate, at 2-4% of the rate with putrescine Ascaris suum CoA + N1-acetylspermine
-
?
acetyl-CoA + sym-norspermidine
-
Ascaris suum CoA + N1-acetyl-sym-norspermidine
-
ir
acetyl-CoA + sym-norspermine at a much lower rate than with sym-norspermidine Ascaris suum CoA + N1-acetyl-sym-norspermine
-
ir
additional information not: histone Ascaris suum ?
-
?
additional information important function in the degradation of diamines of lower eukaryotes Ascaris suum ?
-
?

Subunits

Subunits Comment Organism
? x * ? + x * 13000, catalytic subunit, at least 2 subunits, gel filtration of enzyme precipitated by (NH4)2SO4 Ascaris suum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Ascaris suum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
half-life: above 1 h Ascaris suum
56
-
half-life: less than 0.5 min Ascaris suum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7 7.9
-
Ascaris suum

pH Range

pH Minimum pH Maximum Comment Organism
7.6 8 high conversion rates in the range of Ascaris suum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7
-
N-acetylputrescine
-
Ascaris suum