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Literature summary for 2.3.1.56 extracted from

  • Arlt, V.M.; Glatt, H.; Muckel, E.; Pabel, U.; Sorg, B.L.; Schmeiser, H.H.; Phillips, D.H.
    Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase (2002), Carcinogenesis, 23, 1937-1945.
    View publication on PubMed

Application

Application Comment Organism
medicine metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of isoforms 1 and 2 in chinese hamster lung fibroblast derived cell line V79MZ and in TA1538-derived Salmonella typhimurium strains Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoforms NAT1 and NAT2
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information metabolic activation by isoforms 1 and 2 of 3-nitrobenzanthrone and N-acetyl-N-hydroxy-3-aminobenzantrone, 2 compounds with high mutagenic and genotoxic potential, formation of DNA adducts Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NAT
-
Homo sapiens