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Literature summary for 2.3.1.54 extracted from

  • Kim, S.; Lee, J.; Lee, S.; Ha, J.; Lee, J.; Choi, Y.; Oh, H.; Yoon, Y.; Choi, K.
    Invasion of intestinal cells by Staphylococcus aureus is mediated by pyruvate formate lyase (Pfl) protein (2019), J. Pure Appl. Microbiol., 13, 647-652 .
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DC10B cells Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + formate Staphylococcus aureus
-
 CoA + pyruvate
-
 r
acetyl-CoA + formate Staphylococcus aureus NCCP10862
-
 CoA + pyruvate
-
 r
acetyl-CoA + formate Staphylococcus aureus KACC10768
-
 CoA + pyruvate
-
 r
CoA + pyruvate Staphylococcus aureus
-
 acetyl-CoA + formate
-
 r
CoA + pyruvate Staphylococcus aureus NCCP10862
-
 acetyl-CoA + formate
-
 r
CoA + pyruvate Staphylococcus aureus KACC10768
-
 acetyl-CoA + formate
-
 r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus KACC10768
-
-
-
Staphylococcus aureus NCCP10862
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + formate
-
 Staphylococcus aureus CoA + pyruvate
-
 r
acetyl-CoA + formate
-
 Staphylococcus aureus NCCP10862 CoA + pyruvate
-
 r
acetyl-CoA + formate
-
 Staphylococcus aureus KACC10768 CoA + pyruvate
-
 r
CoA + pyruvate
-
 Staphylococcus aureus acetyl-CoA + formate
-
 r
CoA + pyruvate
-
 Staphylococcus aureus NCCP10862 acetyl-CoA + formate
-
 r
CoA + pyruvate
-
 Staphylococcus aureus KACC10768 acetyl-CoA + formate
-
 r

Synonyms

Synonyms Comment Organism
PFL
-
 Staphylococcus aureus
pyruvate formate lyase
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction an enzyme-deletion mutant reveals a 60% decrease in invasion efficiency when compared to the wild type Staphylococcus aureus
physiological function the enzyme is involved in the invasion of intestinal cells Staphylococcus aureus