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Literature summary for 2.3.1.51 extracted from

  • Saito, M.; Endo, K.; Kobayashi, K.; Watanabe, M.; Ikeuchi, M.; Murakami, A.; Murata, N.; Wada, H.
    High myristic acid content in the cyanobacterium Cyanothece sp. PCC 8801 results from substrate specificity of lysophosphatidic acid acyltransferase (2018), Biochim. Biophys. Acta, 1863, 939-947 .
    View publication on PubMed
Search for more literature for 2.3.1.51

Cloned(Commentary)

Cloned (Comment) Organism
gene PCC8801_1274, DNA and amino acid sequence determination and analysis, recombinant expression in Synechocystis sp. strain PCC 6803 resulting in and increase of the level of 14:0 from 2% to 16% of total fatty acids and decrease of 16:0 from 56% to 43%, analysis of the lipid composition, fatty acid composition of lipid classes and positional distribution of fatty acids, overview Rippkaea orientalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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 Rippkaea orientalis 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate Rippkaea orientalis
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 acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate
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 ?
additional information Rippkaea orientalis analysis of distribution of fatty acids at sn-positions of glycerol moiety of glycerolipids, overview ?
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Organism

Organism UniProt Comment Textmining
Rippkaea orientalis B7K3J7 i.e. Cyanothece sp. PCC 8801
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
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 Rippkaea orientalis acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate
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 ?
acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate the enzyme has a high substrate specificity toward 14:0-ACP Rippkaea orientalis acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate
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 ?
additional information analysis of distribution of fatty acids at sn-positions of glycerol moiety of glycerolipids, overview Rippkaea orientalis ?
-
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myristoyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate
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 Rippkaea orientalis acyl-carrier protein + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
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 ?

Synonyms

Synonyms Comment Organism
1-acyl-sn-glycerol-3-phosphate acyltransferase
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 Rippkaea orientalis
LPA acyltransferase
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 Rippkaea orientalis
lysophosphatidic acid acyltransferase
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 Rippkaea orientalis
PCC8801_1274
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 Rippkaea orientalis

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of glycerolipids in Cyanothece sp. PCC 8801, overview Rippkaea orientalis
physiological function the high content of 14:0 in Cyanothece sp. PCC 8801 might be a result of the high specificity of the 1-acyl-sn-glycerol-3-phosphate acyltransferase activity toward the 14:0-acyl-carrier protein. The 14:0 fatty acid is esterified primarily to the sn-2 position of the glycerol moiety of glycerolipids. This characteristic is unique because, in most of the cyanobacterial strains, the sn-2 position is esterified exclusively with C16 fatty acids, generally 16:0. The enzyme from Cyanothece sp. PCC 8801 transfers an acyl group from acyl-acyl-carrier protein (acyl-ACP) to lysophosphatidic acid (LPA) for the synthesis of phosphatidic acid (PA), a precursor of glycerolipids. Fatty acid analysis of total glycerolipids in Cyanothece sp. PCC 8801 reveals that myristic acid (14:0) and linoleic acid [18:2(9,12)] are the two major fatty acids, with minor contributions from palmitic acid (16:0), palmitoleic acid [16:1(9)], stearic acid (18:0), and oleic acid [18:1(9)], overview Rippkaea orientalis