Literature summary for 2.3.1.51 extracted from

Rastegar, F.; Gao, J.L.; Shenaq, D.; Luo, Q.; Shi, Q.; Kim, S.H.; Jiang, W.; Wagner, E.R.; Huang, E.; Gao, Y.; Shen, J.; Yang, K.; He, B.C.; Chen, L.; Zuo, G.W.; Luo, J.; Luo, X.; Bi, Y.; Liu, X.; Li, M.; Hu, N.; Wang, L.; Luther, G.; Luu, H.H.; Haydon, R.C.; He, T.C.
Lysophosphatidic acid acyltransferase beta (LPAATbeta) promotes the tumor growth of human osteosarcoma (2010), PLoS ONE, 5, e14182.

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Application

Application	Comment	Organism
medicine	expression of isoform LPAATbeta is readily detected in 8 of 10 analyzed human osteosarcoma lines. Exogenous expression of LPAATbeta promotes osteosarcoma cell proliferation and migration, while silencing LPAATbeta expression inhibits these cellular characteristics. Exogenous expression of LPAATbeta effectively promotes tumor growth, while knockdown of LPAATbeta expression inhibits tumor growth in an orthotopic xenograft model of human osteosarcoma	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in osteosarcoma cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15120	-	-

Synonyms

Synonyms	Comment	Organism
1-Agpat2	-	Homo sapiens
LPAATbeta	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	expression of isoform LPAATbeta is readily detected in 8 of 10 analyzed human osteosarcoma lines. Exogenous expression of LPAATbeta promotes osteosarcoma cell proliferation and migration, while silencing LPAATbeta expression inhibits these cellular characteristics.Exogenous expression of LPAATbeta effectively promotes tumor growth, while knockdown of LPAATbeta expression inhibits tumor growth in an orthotopic xenograft model of human osteosarcoma	Homo sapiens

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Release 2023.1 (January 2023)