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Literature summary for 2.3.1.51 extracted from

  • Koeberle, A.; Shindou, H.; Harayama, T.; Yuki, K.; Shimizu, T.
    Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3 (2012), FASEB J., 26, 169-180.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus C4B4E7
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-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
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Mus musculus
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Synonyms

Synonyms Comment Organism
AGPAT3
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Mus musculus
LPAAT3
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Mus musculus

Expression

Organism Comment Expression
Mus musculus isoform LPAAT3 is induced during germ cell maturation. Differentiation of mouse GC-2spd(ts) spermatocytes into spermatides up-regulates isoform LPAAT3 mRNA, increases the amount of polyunsaturated phospholipids, and shifts the specificity for the incorporation of docosahexaenoic acid toward phosphatidylcholine and phosphatidylethanolamine up

General Information

General Information Comment Organism
physiological function isoform LPAAT3 is induced during germ cell maturation. Differentiation of mouse GC-2spd(ts) spermatocytes into spermatides up-regulates isoform LPAAT3 mRNA, increases the amount of polyunsaturated phospholipids, and shifts the specificity for the incorporation of docosahexaenoic acid toward phosphatidylcholine and phosphatidylethanolamine. Stable knockdown of LPAAT3 in GC-2spd(ts) cells significantly decreases microsomal LPAAT3 activity, reduces levels of polyunsaturated phosphatidylethanolamine species, and impairs cell proliferation/survival during geneticin selection Mus musculus