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Literature summary for 2.3.1.51 extracted from
- Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells (2010), FASEB J., 24, 4929-4938.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0138 | - |
docosahexaenoyl-CoA | pH 7.5, 37°C | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | C4B4E7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | minor substrate | Mus musculus | CoA + 1-oleoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
| docosahexaenoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | best substrates | Mus musculus | CoA + 1-oleoyl-2-docosahexaenoyl-sn-glycerol 3-phosphate | - |
? | |
| additional information | isoform LPAAT3 shows a clear preference for 18:1-lyso-PA as acyl acceptor and 22:6-CoA as acyl donor compared to other substrate combinations tested. The respective product sn-1-18:1-sn-2-22:6-phosphatidic acid is almost exclusively formed by LPAAT3. The enzyme shows Michaelis-Menten rate behavior toward 22:6-CoA in the presence of sn-1-18:1-lyso-phosphatidic acid | Mus musculus | ? | - |
? | |
| oleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate | minor substrate | Mus musculus | CoA + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LPAAT3 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | stable transfection of TM4 Sertoli cells with isoform LPAAT3-small hairpin RNA leads to decreases in arachidonoyl-, eicosapentaenoyl-, and docosapentaenoyl-containing phosphatidylcholine and linoleoyl-containing phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. Expression of murine LPAAT3 in Chinese hamster ovary K1 cells has essentially an opposite effect. The level of polyunsaturated phosphatidylcholine correlates with cellular levels of free docosapentaenoic acid and eicosapentaenoic acid in TM4 and Chinese hamster ovary K1 cells, respectively | Mus musculus |
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Release 2023.1 (January 2023)
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