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Literature summary for 2.3.1.50 extracted from

  • Wei, J.; Yerokun, T.; Leipelt, M.; Haynes, C.A.; Radhakrishna, H.; Momin, A.; Kelly, S.; Park, H.; Wang, E.; Carton, J.M.; Uhlinger, D.J.; Merrill, A.H.
    Serine palmitoyltransferase subunit 1 is present in the endoplasmic reticulum, nucleus and focal adhesions, and functions in cell morphology (2009), Biochim. Biophys. Acta, 1791, 746-756.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information elimination of subunit SPT1 activity using SPTLC1 siRNA in HEK-293 cells causes cell rounding Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum SPT subunit 1 is present in the endoplasmic reticulum Homo sapiens 5783
-
additional information in addition to its localization in the endoplasmic reticulum for de novo sphingolipid biosynthesis, subunit SPT1 is present in other cellular compartments, including focal adhesions where it is associated with cell morphology, immunofluorescent subcellular localization study, overview Homo sapiens
-
-
additional information SPT subunit 1, it binds to the focal adhesion protein vinculin Homo sapiens
-
-
nucleus SPT subunit 1 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens
-
CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15269 subunits SPT1 and SPT2
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
Homo sapiens
SPT
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

General Information

General Information Comment Organism
physiological function in the endoplasmic reticulum subunit SPT1 is responsible for de novo sphingolipid biosynthesis, it is also present in other cellular compartments, including focal adhesions where it is associated with cell morphology Homo sapiens