Literature summary for 2.3.1.50 extracted from

Park, T.S.; Rosebury, W.; Kindt, E.K.; Kowala, M.C.; Panek, R.L.
Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice (2008), Pharmacol. Res., 58, 45-51.

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Application

Application	Comment	Organism
medicine	results show that the inhibition of atherosclerosis by the serine palmitoyltransferase inhibitor myriocin in apolipoprotein-E gene knockout mice is associated with reduced plasma glycosphingolipid and plasma sphingomyelin concentration	Mus musculus
medicine	the SPT inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
myriocin	the inhibition of SPT in hyperlipidemic apolipoprotein E knockout mice lowers plasma sphingolipids and atherogenic plasma lipids leading to the regression of pre-existing atherosclerotic lesions and to the formation of a stable plaque phenotype	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
serine palmitoyltransferase	-	Mus musculus
SPT	-	Mus musculus

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Release 2023.1 (January 2023)