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Literature summary for 2.3.1.50 extracted from
- Pioglitazone induces de novo ceramide synthesis in the rat heart (2007), Prostaglandins Other Lipid Mediat., 83, 99-111.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme activity and expression in the heart is not affected by high-fat feeding | Rattus norvegicus | |
| pioglitazone | increases the enzyme activity in vitro and in vivo independent of standard or high-fat diet | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme activity and expression in the heart is not affected by high-fat feeding | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the enzyme activity and expression in the heart is not affected by high-fat feeding | ? | - |
? | |
| palmitoyl-CoA + L-serine | Rattus norvegicus | the enzyme is involved in the ceramide metabolism, overview | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
isozyme SPT2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | isozyme SPT2 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme activity and expression in the heart is not affected by high-fat feeding | Rattus norvegicus | ? | - |
? | |
| palmitoyl-CoA + L-serine | - |
Rattus norvegicus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
| palmitoyl-CoA + L-serine | the enzyme is involved in the ceramide metabolism, overview | Rattus norvegicus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine palmitoyltransferase | - |
Rattus norvegicus |
| SPT | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | - |
about, assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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