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Literature summary for 2.3.1.50 extracted from

  • Yamaji-Hasegawa, A.; Takahashi, A.; Tetsuka, Y.; Senoh, Y.; Kobayashi, T.
    Fungal metabolite sulfamisterin suppresses sphingolipid synthesis through inhibition of serine palmitoyltransferase (2005), Biochemistry, 44, 268-277.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R)-2-amino-12-hydroxy-2-hydroxymethyl-3-sulfooxy-octadecanoic acid IC50: 5.4 nM Cricetulus griseus
(2S,3R)-2-amino-12-[(Z)-hydroxyimino]-2-hydroxymethyl-3-sulfooxy-octadecanoic acid IC50: 30 nM Cricetulus griseus
(2S,3R)-2-amino-3,12-dihydroxy-2-hydroxymethyl-octadecanoic acid IC50: 3.2 nM Cricetulus griseus
(2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid IC50: 3.5 nM Cricetulus griseus
(2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid methyl ester IC50: 17 nM Cricetulus griseus
myriocin
-
Cricetulus griseus
sulfamisterin antibiotic derived from Pycnidiella sp., IC50: 3 nM Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Cricetulus griseus key enzyme of sphingolipid metabolism CoA + 3-dehydro-D-sphinganine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine key enzyme of sphingolipid metabolism Cricetulus griseus CoA + 3-dehydro-D-sphinganine + CO2
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
antibiotic derived from Pycnidiella sp., IC50: 3 nM Cricetulus griseus sulfamisterin
0.0000032
-
IC50: 3.2 nM Cricetulus griseus (2S,3R)-2-amino-3,12-dihydroxy-2-hydroxymethyl-octadecanoic acid
0.0000035
-
IC50: 3.5 nM Cricetulus griseus (2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid
0.0000054
-
IC50: 5.4 nM Cricetulus griseus (2S,3R)-2-amino-12-hydroxy-2-hydroxymethyl-3-sulfooxy-octadecanoic acid
0.000017
-
IC50: 17 nM Cricetulus griseus (2S,3R)-2-amino-3-hydroxy-2-hydroxymethyl-12-oxo-octadecanoic acid methyl ester
0.00003
-
IC50: 30 nM Cricetulus griseus (2S,3R)-2-amino-12-[(Z)-hydroxyimino]-2-hydroxymethyl-3-sulfooxy-octadecanoic acid