Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.50 extracted from

  • Merrill, A.H.; Wang, E.
    Enzymes of ceramide biosynthesis (1992), Methods Enzymol., 209, 427-437.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
beta-Haloalanines
-
Rattus norvegicus
L-Cycloserine
-
Rattus norvegicus
L-Cycloserine
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1 1 L-serine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microsome
-
Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Rattus norvegicus initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine Saccharomyces cerevisiae initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine Prevotella melaninogenica initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
ir

Organism

Organism UniProt Comment Textmining
Prevotella melaninogenica
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Saccharomyces cerevisiae
additional information
-
assay method Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine
-
Prevotella melaninogenica CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine palmitoyl-CoA is the preferred substrate Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine no other amino acids can substitute for serine Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
ir
palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Prevotella melaninogenica CoA + 3-dehydro-D-sphinganine + CO2
-
ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required for activity Saccharomyces cerevisiae
pyridoxal 5'-phosphate pyridoxal 5'-phosphate can be resolved from the enzyme by dialysis Rattus norvegicus