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Literature summary for 2.3.1.5 extracted from

  • Witham, K.L.; Minchin, R.F.; Butcher, N.J.
    Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway (2017), Biochem. Pharmacol., 125, 93-100 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P18440
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
-
Homo sapiens
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MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-436 cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
NAT1
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Homo sapiens

General Information

General Information Comment Organism
physiological function following NAT1 knockdown with shRNA, acetylation of p-aminobenzoylglutamate is significantly decreased, while there are no changes in intracellular p-aminobenzoylglutamate or the components of the SAM cycle. The flux of homocysteine in the medium is different following NAT1 knockdown after the methionine content is exhausted. NAT1 knockdown inhibits the methionine salvage pathway in HT-29 cells but not in HeLa or MDA-MB-436 cells Homo sapiens