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Literature summary for 2.3.1.5 extracted from

  • Doll, M.A.; Salazar-Gonzalez, R.A.; Bodduluri, S.; Hein, D.W.
    Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes (2017), Acta Pharm. Sin. B, 7, 517-522 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine isoniazid N-acetylation rates in vitro exhibit a robust and highly significant NAT2 phenotype-dependent metabolism. N-acetylation rates in situ are isoniazid concentration- and time-dependent. Following incubation for 24 h with 12.5 or 100 mmol/l isoniazid, acetyl-isoniazid concentrations vary significantly across cryopreserved human hepatocytes samples from rapid, intermediate, and slow acetylators, respectively. N-acetylation rates of N-(4-aminobenzoyl)-L-glutamate in vitro do not differ significantly between rapid, intermediate, and slow NAT2 acetylators. N-acetylation rates towards isoniazid in the identical samples exhibit a robust and highly significant NAT2 genotype-dependent metabolism Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + isoniazid
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 Homo sapiens CoA + N-acetyl-isoniazid
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 ?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate
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 Homo sapiens CoA + CoA + N-(4-acetylaminobenzoyl)-L-glutamate
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 ?