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Literature summary for 2.3.1.5 extracted from
- Interaction of human arylamine N-acetyltransferase 1 with different nanomaterials (2014), Drug Metab. Dispos., 42, 377-383.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thermo-responsive diblock copolymer nanoparticle | - |
Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is inhibited by layered silicate nanoparticles and layered double hydroxide clays | Homo sapiens | |
| SiO2 | - |
Homo sapiens |  |
| TiO2 | - |
Homo sapiens | |
| ZnO | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.106 | - |
4-Aminobenzoate | at pH 7.4 and 37°C | Homo sapiens | |
| 0.438 | - |
acetyl-CoA | at pH 7.4 and 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
x * 33000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 4-aminobenzoate | - |
Homo sapiens | CoA + N-acetyl-4-aminobenzoate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 33000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arylamine-N-acetyltransferase 1 | - |
Homo sapiens |
| NAT1 | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | 47 | NAT1 is sensitive to heat denaturation and shows a significant loss in activity as temperature is increased from 37°C to 47°C | Homo sapiens |
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Release 2023.1 (January 2023)
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