Literature summary for 2.3.1.5 extracted from

Stepp, M.W.; Mamaliga, G.; Doll, M.A.; States, J.C.; Hein, D.W.
Folate-dependent hydrolysis of acetyl-coenzyme A by recombinant human and rodent arylamine N-acetyltransferases (2015), Biochem. Biophys. Rep., 3, 45-50.

Search for more literature for 2.3.1.5

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli JM105 cells	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0543	-	acetyl-CoA	isoform NAT1, at 37°C, pH not specified in the publication	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + 4-aminobenzoate	-	Homo sapiens	CoA + N-acetyl-4-aminobenzoate	-	?
additional information	isoform NAT1 catalyzes acetyl-CoA hydrolysis in a folate-dependent manner, while isoform NAT2 does not	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
NAT1	isoform	Homo sapiens
NAT2	isoform	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
folate	isoform NAT1 catalyzes acetyl-CoA hydrolysis in a folate-dependent manner, while isoform NAT2 does not	Homo sapiens

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Release 2023.1 (January 2023)