Literature summary for 2.3.1.5 extracted from

Erickson, R.; Cao, W.; Acuna, D.; Strnatka, D.; Hunter, R.; Chau, B.; Wakefield, L.; Sim, E.; Mcqueen, C.
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts (2008), Mol. Reprod. Dev., 75, 1071-1076.

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Application

Application	Comment	Organism
medicine	increasing acetylation by introduction of the human NAT1 transgene is protective against sporadic dilantin-induced orofacial clefting defects in the mouse A/J strain	Homo sapiens
medicine	knockout of NAT2 significantly decreases teratogen-induced orofacial clefting in the A/J strain, but not in the C57BL/6J strain	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

General Information

General Information	Comment	Organism
physiological function	increasing acetylation by introduction of the human NAT1 transgene is protective against sporadic dilantin-induced orofacial clefting defects in the mouse A/J strain	Homo sapiens
physiological function	knockout of NAT2 significantly decreases teratogen-induced orofacial clefting in the A/J strain, but not in the C57BL/6J strain	Mus musculus

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Release 2023.1 (January 2023)