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Literature summary for 2.3.1.5 extracted from

  • Takubo, K.; Tsuchiya, H.; Kurimasa, A.; Arnesen, T.; Ryoke, K.; Shiota, G.
    Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil (2009), Anticancer Drugs, 20, 668-675.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEp-2 cell
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Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens 5-fluorouracil decreases N-acetyltransferase expression down

General Information

General Information Comment Organism
physiological function knockdown of N-acetyltransferase by siRNA results in downregulation of thymidylate synthase mRNA expression and induced apoptosis. N-acetyltransferase overexpression facilitates cell proliferation independent of the presence of 5-fluorouracil Homo sapiens