Literature summary for 2.3.1.5 extracted from

Kubota, R.; Ohno, M.; Hasunuma, T.; Iijima, H.; Azuma, J.
Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2 (2007), Eur. J. Clin. Pharmacol., 63, 927-933.

Search for more literature for 2.3.1.5

Application

Application	Comment	Organism
medicine	the internationally recommended dosage of isoniazid for patients with two active NAT2 alleles in order to achieve appropriate antituberculous efficiency should be increased	Homo sapiens
medicine	to estimate an optimal dosage for isoniazid (INH) RA-type patients (patients with two active NAT2 alleles due to genetic polymorphisms) a dose escalation study in healthy male volunteers is conducted carrying mutation NAT24/4. In RA-type subjects, the pharmacokinetic parameters appear to lack linearity with the increased dose of isoniazid. It is proposed that the proper daily dose for RA-type patients is 1.5times higher than that currently recommended	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C190T	NAT2 single nucleotide polymorphism	Homo sapiens
C481T	NAT2 single nucleotide polymorphism	Homo sapiens
G191A	NAT2 single nucleotide polymorphism	Homo sapiens
G590A	NAT2 single nucleotide polymorphism	Homo sapiens
G857A	NAT2 single nucleotide polymorphism	Homo sapiens
T341C	NAT2 single nucleotide polymorphism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + isoniazid	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
arylamine N-acetyltransferase 2	-	Homo sapiens
NAT2	-	Homo sapiens

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Release 2023.1 (January 2023)