Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glycyrrhizic acid | slightly activates isozyme NAT1 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | inhibitors of NAT enzymes may be valuable as chemopreventive agents | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epigallocatechin-3-O-gallate | EGCG, non-competitive | Homo sapiens | |
caffeic acid | non-competitive | Homo sapiens | |
curcumin | non-competitive | Homo sapiens | |
esculetin | - |
Homo sapiens | |
ferulic acid | - |
Homo sapiens | |
gallic acid | - |
Homo sapiens | |
genistein | - |
Homo sapiens | |
kaemferol | non-competitive; non-competitive | Homo sapiens | |
additional information | inhibitory potency of flavonoids on isozyme NAT1, no inhibition by curcumin, silymarin, and scopoletin, overview; inhibitory potency of flavonoids on isozyme NAT2, no inhibition by ()epigallocatechin gallate, gallic acid, caffeic acid, and ferulic acid, overview | Homo sapiens | |
quercetin | non-competitive; non-competitive | Homo sapiens | |
scopoletin | - |
Homo sapiens | |
silymarin | - |
Homo sapiens | |
taxifolin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme NAT1 | Homo sapiens | 5829 | - |
cytosol | isozyme NAT2 | Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | Homo sapiens | NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines | CoA + an N-acetylarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11245 | isozyme NAT2; isozyme NAT2 | - |
Homo sapiens | P18440 | isozyme NAT1; isozyme NAT1 | - |
Purification (Comment) | Organism |
---|---|
native enzyme partially by subcellular fractionation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cholangiocarcinoma cell | isozyme NAT1 | Homo sapiens | - |
KMBC cell | a cholangiocarcinoma cell line, isozyme NAT1 | Homo sapiens | - |
liver | isozyme NAT1 | Homo sapiens | - |
liver | isozyme NAT2 | Homo sapiens | - |
additional information | no isozyme NAT2 activity in cholangiocarcinoma cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 4-aminobenzoic acid | isozyme NAT1 | Homo sapiens | CoA + N-acetyl-4-aminobenzoic acid | - |
? | |
acetyl-CoA + an arylamine | - |
Homo sapiens | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + an arylamine | NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines | Homo sapiens | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + sulfamethazine | isozyme NAT2 | Homo sapiens | CoA + N-acetyl-sulfamethazine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, isozyme NAT1 | Homo sapiens | |
additional information | - |
additional information | inhibition kinetics, isozyme NAT2 | Homo sapiens | |
0.01 | - |
quercetin | isozyme NAT2 | Homo sapiens | |
0.0486 | - |
quercetin | isozyme NAT1 | Homo sapiens |