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Literature summary for 2.3.1.5 extracted from

  • Barker, D.F.; Husain, A.; Neale, J.R.; Martini, B.D.; Zhang, X.; Doll, M.A.; States, J.C.; Hein, D.W.
    Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1 (2006), Pharmacogenet. Genomics, 16, 515-525.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
NAT1, DNA and amino acid sequence determination and analysis, exon composition, expression analysis, identification of an alternative NAT1 promoter lying 51.5 kb upstream of the NAT1 ORF, all NAT1 P3 mRNAs included 5'-untranslated region internal exons of 61 and 175 nucleotides in addition to the 79 nucleotide 5'-untranslated region exon present in P1 mRNA CAP-dependent amplification of 50-P3 mRNA termini defined an 84 base pair transcription start region in which most start sites are centrally clustered, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell the hepatoma-derived cell line expresses a high level of P3 mRNA with the same spliced structure and start site pattern as found in normal tissues Homo sapiens
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kidney high activity of isozyme NAT1 Homo sapiens
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liver high activity of isozyme NAT1 Homo sapiens
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lung high activity of isozyme NAT1 Homo sapiens
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additional information isozyme NAT1 tissue-specific expression, analysis, overview Homo sapiens
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trachea high activity of isozyme NAT1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
NAT
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Homo sapiens