Cloned (Comment) | Organism |
---|---|
gene NAT1, DNA and amino acid sequence determination and analysis, genetic organization, several splice variants of the NAT1 gene that are expressed from different promoters, expression analysis, the NAT1 gene is located on chromosome 8 at 8p21-22, a region known to be deleted in many human cancers | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutations responsible for reduced NAT1 stability and down-regulation occur in nature, the NAT1 slow acetylator phenotype is associated with a protection against spina bifida, a condition that is linked to the level of maternal folic acid intake | Homo sapiens |
additional information | NAT1*10, phenotype has higher than normal activity in some tissues, associated with increased risk of cancer | Homo sapiens |
additional information | NAT1*14, slow acetylator phenotype, loss of function alleles | Homo sapiens |
additional information | NAT1*15, slow acetylator phenotype, loss of function alleles | Homo sapiens |
additional information | NAT1*17, slow acetylator phenotype, loss of function alleles | Homo sapiens |
additional information | NAT1*19, slow acetylator phenotype, loss of function alleles | Homo sapiens |
additional information | NAT1*22, slow acetylator phenotype, loss of function alleles | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
soluble | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
- |
Homo sapiens |
33000 | - |
x * 33000, soluble NAT1, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | Homo sapiens | - |
CoA + an N-acetylarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P18440 | isozyme NAT1; isozyme NAT1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine | molecular mechanism of arylamine acetylation by the catalytic triad of NAT1, overview, the catalytic triad is formed by Cys68, His107, and Asp122 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | - |
Homo sapiens | CoA + an N-acetylarylamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 33000, soluble NAT1, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase I | - |
Homo sapiens |
NAT | - |
Homo sapiens |
NAT1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |