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Literature summary for 2.3.1.5 extracted from
- Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines (2005), In Vivo, 19, 1061-1070.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM and the further metabolism of the product of the enzyme catalytic reaction 2-acetylaminofluorene in the stomach and colon | Rattus norvegicus |  |
| 5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM in Colo 205 cells, inhibitory at lower dosage of 0.05-0.5 mM in Colo 205 cells and at 0.5-0.25 mM in SC-M1 cells, concentrations of 5-25 mM have no effect in Colo 205 cells | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM in Colo 205 cells, inhibitory at lower dosage of 0.05-0.5 mM, concentrations of 5-25 mM have no effect in Colo 205 cells | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 2-aminofluorene | Homo sapiens | - |
CoA + 2-acetylaminofluorene | - |
? | |
| acetyl-CoA + 2-aminofluorene | Rattus norvegicus | - |
CoA + 2-acetylaminofluorene | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Colo-205 cell | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| colon | high activity | Rattus norvegicus | - |
| SC-M1 cell | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| stomach | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 2-aminofluorene | - |
Homo sapiens | CoA + 2-acetylaminofluorene | - |
? | |
| acetyl-CoA + 2-aminofluorene | - |
Rattus norvegicus | CoA + 2-acetylaminofluorene | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAT | - |
Homo sapiens |
| NAT | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Homo sapiens | |
| acetyl-CoA | - |
Rattus norvegicus | |
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