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Literature summary for 2.3.1.5 extracted from

  • Lo, H.H.; Chung, J.G.
    The effects of plant phenolics, caffeic acid, chlorogenic acid and ferulic acid on arylamine N-acetyltransferase activities in human gastrointestinal microflora (1999), Anticancer Res., 19, 133-139.
    View publication on PubMed
Search for more literature for 2.3.1.5

Inhibitors

Inhibitors Comment Organism Structure
caffeic acid 4 mM, 65.3% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
caffeic acid 4 mM, 37.6% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
caffeic acid 4 mM, 37.9% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
caffeic acid 4 mM, 39.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
caffeic acid 4 mM, 83.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa
chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
chlorogenic acid 4mM, significant inhibitory effect for 4 hours. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
chlorogenic acid dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa
ferulic acid 4 mM, 46.5% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Citrobacter koseri
ferulic acid 4 mM, 35.8% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Escherichia coli
ferulic acid 4 mM, 41.4% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella aerogenes
ferulic acid 4 mM, 39.7% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Klebsiella pneumoniae
ferulic acid 4 mM, 75.1% suppression. Dose-dependent enzyme inhibition in cytosolic and intact cell examinations Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00019
-
 2-Aminofluorene
-
 Escherichia coli
0.00055
-
 2-Aminofluorene
-
 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Citrobacter koseri
-
-
-
Escherichia coli
-
-
-
Klebsiella aerogenes
-
-
-
Klebsiella pneumoniae
-
-
-
Pseudomonas aeruginosa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 Vmax 0.0034 Escherichia coli
additional information
-
 Vmax 0.0293 Pseudomonas aeruginosa
0.000162
-
 cytosol Escherichia coli
0.00068
-
 cytosol Klebsiella pneumoniae
0.00478
-
 cytosol Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene
-
 Escherichia coli CoA + N-acetyl-2-aminofluorene
-
 ?
acetyl-CoA + 2-aminofluorene
-
 Klebsiella aerogenes CoA + N-acetyl-2-aminofluorene
-
 ?
acetyl-CoA + 2-aminofluorene
-
 Pseudomonas aeruginosa CoA + N-acetyl-2-aminofluorene
-
 ?
acetyl-CoA + 2-aminofluorene
-
 Klebsiella pneumoniae CoA + N-acetyl-2-aminofluorene
-
 ?
acetyl-CoA + 2-aminofluorene
-
 Citrobacter koseri CoA + N-acetyl-2-aminofluorene
-
 ?