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Literature summary for 2.3.1.48 extracted from

  • Lamparter, C.; Winn, L.
    Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells (2016), Toxicol. Appl. Pharmacol., 306, 69-78 .
    View publication on PubMed
Search for more literature for 2.3.1.48

Inhibitors

Inhibitors Comment Organism Structure
C646
-
 Mus musculus
Valproic acid
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine Mus musculus
-
 CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus B2RWS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
P-19 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine
-
 Mus musculus CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
Cbp
-
 Mus musculus
HAT
-
 Mus musculus
p300
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of nuclear and total cellular enzyme proteins is decreased following 5 mM valproic acid exposure for 6 h down

General Information

General Information Comment Organism
malfunction enzyme deficiency is associated with congenital malformations and embryolethality. Enzyme inhibition induces oxidative stress Mus musculus