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Literature summary for 2.3.1.48 extracted from

  • Deng, W.; Wang, C.; Zhang, Y.; Xu, Y.; Zhang, S.; Liu, Z.; Xue, Y.
    GPS-PAIL prediction of lysine acetyltransferase-specific modification sites from protein sequences (2016), Sci. Rep., 6, 39787 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [protein]-L-lysine Homo sapiens
-
CoA + [protein]-N6-acetyl-L-lysine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14929
-
-
Homo sapiens Q09472
-
-
Homo sapiens Q92793
-
-
Homo sapiens Q92830
-
-
Homo sapiens Q92831
-
-
Homo sapiens Q92993
-
-
Homo sapiens Q9H7Z6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [protein]-L-lysine
-
Homo sapiens CoA + [protein]-N6-acetyl-L-lysine
-
?
additional information substrate site specificity, overview Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
CREBBP
-
Homo sapiens
EP300
-
Homo sapiens
HAT
-
Homo sapiens
histone acetyltransferases
-
Homo sapiens
KAT
-
Homo sapiens
Kat2A
-
Homo sapiens
Kat2b
-
Homo sapiens
KAT5
-
Homo sapiens
KAT8
-
Homo sapiens
lysine acetyltransferase
-
Homo sapiens
lysine acetyltransferase 2A
-
Homo sapiens
lysine acetyltransferase 2B
-
Homo sapiens
lysine acetyltransferase 5
-
Homo sapiens
lysine acetyltransferase 8
-
Homo sapiens
p300 HAT UniProt Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

General Information

General Information Comment Organism
additional information screening of 544 human HAT-specific sites for acetylation by different HATs. Development the GPS 2.2 algorithm for the prediction of APC/C recognition motifs such as D-boxes and KEN-boxes proteins. The algorithm comprises two major parts, including the scoring strategy and performance improvement, method, overview Homo sapiens
physiological function protein acetylation catalyzed by specific histone acetyltransferases (HATs) is an essential posttranslational modification (PTM) and involved in the regulation a broad spectrum of biological processes in eukaryotes Homo sapiens