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Literature summary for 2.3.1.48 extracted from
- Roles for lysine acetyltransferases during mammalian hibernation (2018), J. Therm. Biol., 74, 71-76 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + [histone H3]-L-lysine9 | Ictidomys tridecemlineatus | - |
CoA + [histone H3]-N6-acetyl-L-lysine9 | - |
? |  |
| acetyl-CoA + [protein]-L-lysine | Ictidomys tridecemlineatus | - |
CoA + [protein]-N6-acetyl-L-lysine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ictidomys tridecemlineatus | I3M1C6 | - |
- |
| Ictidomys tridecemlineatus | I3M5C0 | - |
- |
| Ictidomys tridecemlineatus | I3M864 | - |
- |
| Ictidomys tridecemlineatus | I3MK28 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brown adipose tissue | - |
Ictidomys tridecemlineatus | - |
| liver | - |
Ictidomys tridecemlineatus | - |
| additional information | tissue-specific response of KATs, particularly in the adipose tissues where specific KATs (PCAF and GCN5L2), HAT activity, and H3K9ac increase in the metabolically active brown adipose tissue while HAT1, HAT activity and H3K9ac decrease in white adipose tissue. Liver shows significant increases in the KAT PCAF whereas skeletal muscle decreases CBP and GCN5L2. Both liver and skeletal muscle show no change in HAT activity and H3K9me3 increases in muscle during torpor. In liver, protein levels of CBP are significantly reduced to during interbout arousal (IA) as compared to values for animals that are euthermic in the cold room. In skeletal muscle, CBP protein levels are significantly reduced during late torpor (LT). Levels of CBP do not fluctuate significantly over the course of the torpor-arousal cycle | Ictidomys tridecemlineatus | - |
| additional information | tissue-specific response of KATs, particularly in the adipose tissues where specific KATs (PCAF and GCN5L2), HAT activity, and H3K9ac increase in the metabolically active brown adipose tissue while HAT1, HAT activity and H3K9ac decrease in white adipose tissue. Liver shows significant increases in the KAT PCAF whereas skeletal muscle decreases CBP and GCN5L2. Both liver and skeletal muscle show no change in HAT activity and H3K9me3 increases in muscle during torpor. Levels of PCAF are significantly elevated over controls during four stages: entrance into torpor (EN), early torpor (ET), late torpor (LT) and early arousal. Protein levels of PCAF do not change significantly over torpor-arousal. In brown adipose tissue, protein levels of PCAF are significantly elevated during EN by 1.9fold over cold room (EC) | Ictidomys tridecemlineatus | - |
| additional information | tissue-specific response of KATs, particularly in the adipose tissues where specific KATs (PCAF and GCN5L2), HAT activity, and H3K9ac increase in the metabolically active brown adipose tissue while HAT1, HAT activity and H3K9ac decrease in white adipose tissue. Liver shows significant increases in the KAT PCAF whereas skeletal muscle s decreased CBP and GCN5L2. Both liver and skeletal muscle show no change in HAT activity and H3K9me3 increases in muscle during torpor. No significant fluctuations are observed for protein levels of HAT1 in liver over the torpor-arousal cycle. Protein levels of HAT1 do not change significantly over torpor-arousal. Protein levels of HAT1 in brown adipose tissue are significantly reduced during early torpor (ET) and interbout arousal (IA) to 0.6 of cold room (EC) level | Ictidomys tridecemlineatus | - |
| additional information | tissue-specific response of KATs, particularly in the adipose tissues where specific KATs (PCAF and GCN5L2), HAT activity, and H3K9ac increase in the metabolically active brown adipose tissue while HAT1, HAT activity and H3K9ac decrease in white adipose tissue. Liver shows significant increases in the KAT PCAF whereas skeletal muscles decreased CBP and GCN5L2. Both liver and skeletal muscle show no change in HAT activity and H3K9me3 increases in muscle during torpor. Protein levels of GCN5L2 are significantly decreased during late torpor (LT) when compared to early torpor (ET), and subsequently increased during early arousal (EA)by 1.4fold over controls. GCN5L2 are significantly lowered during topor (EN), LT, EA and IA, but not during ET. Levels of GCN5L2 are also elevated during LT by 1.4fold before significantly decreasing during interbout arousal (IA) to 0.7 of cold room (EC) | Ictidomys tridecemlineatus | - |
| skeletal muscle | - |
Ictidomys tridecemlineatus | - |
| white adipose tissue | - |
Ictidomys tridecemlineatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + [histone H3]-L-lysine9 | - |
Ictidomys tridecemlineatus | CoA + [histone H3]-N6-acetyl-L-lysine9 | - |
? | |
| acetyl-CoA + [protein]-L-lysine | - |
Ictidomys tridecemlineatus | CoA + [protein]-N6-acetyl-L-lysine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cbp | - |
Ictidomys tridecemlineatus |
| CREBBP | - |
Ictidomys tridecemlineatus |
| Gcn5 | - |
Ictidomys tridecemlineatus |
| GCN5L2 | - |
Ictidomys tridecemlineatus |
| HAT | - |
Ictidomys tridecemlineatus |
| Hat1 | - |
Ictidomys tridecemlineatus |
| KAT | - |
Ictidomys tridecemlineatus |
| lysine acetyltransferases | - |
Ictidomys tridecemlineatus |
| PCAF | - |
Ictidomys tridecemlineatus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Ictidomys tridecemlineatus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | four KATs (CBP, PCAF, GCN5L2, HAT1) perform acetylation of histone H3 lysine 9 (H3K9ac) in multiple tissues across the torpor-arousal cycle, determination of protein levels | Ictidomys tridecemlineatus |
| physiological function | lysine acetyltransferases (KATs) play a crucial role in modulating the expression and activity of a wide-variety of cellular pathways and processes, and therefore, may play a role during hibernation when the cell is shifting to an energy conservative, cytoprotective state. Roles for lysine acetyltransferases during mammalian hibernation | Ictidomys tridecemlineatus |
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