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Literature summary for 2.3.1.48 extracted from

  • Leaver, D.; Cleary, B.; Nguyen, N.; Priebbenow, D.; Lagiakos, H.; Sanchez, J.; Xue, L.; Huang, F.; Sun, Y.; Mujumdar, P.; Mudududdla, R.; Varghese, S.; Teguh, S.; Charman, S.; White, K.; Katneni, K.; Cuellar, M.; Strasser, J.; Dahlin, J.; Walters, M.
    Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A (2019), J. Med. Chem., 62, 7146-7159 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
2'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
2'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
2-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
2-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
2-fluoro-N'-(phenylsulfonyl)benzohydrazide
-
Mus musculus
2-fluoro-N'-[(3-fluorophenyl)sulfonyl]benzohydrazide
-
Mus musculus
2-fluoro-N'-[[3-(trifluoromethyl)phenyl]sulfonyl]benzohydrazide
-
Mus musculus
2-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
3'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
3'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
3'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
3'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
3-(2-(2-fluorobenzoyl)hydrazinylsulfono)benzamide
-
Mus musculus
3-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
3-chloro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
3-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
3-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
3-fluoro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
3-methyl-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
4'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
4'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
4'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
4'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
-
Mus musculus
4-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
4-butoxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
4-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
4-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
4-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
CTX-0124143 i.e. N'-(2-fluorobenzoyl)naphthalene-2-sulfonohydrazide Mus musculus
N'-( 2-fluoro-[1,1'- biphenyl]-3-carbonyl)-benzenesulfonohydrazide
-
Mus musculus
N'-(2,3-difluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(2,3-difluorobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-dluorobenzoyl)-4-methylbenzenesulfonohydrazide
-
Mus musculus
N'-(2-fluoro-3-(trifluoromethyl)benzoyl)-benzenesulfonohydrazide
-
Mus musculus
N'-(2-fluoro-3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-fluoro-3-methoxybenzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(2-fluoro-3-methylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-fluoro-5-methylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-fluorobenzoyl)-2-methoxybenzenesulfonohydrazide
-
Mus musculus
N'-(2-fluorobenzoyl)-2-methylbenzenesulfonohydrazide
-
Mus musculus
N'-(2-fluorobenzoyl)-3-methoxybenzenesulfonohydrazide
-
Mus musculus
N'-(2-fluorobenzoyl)-3-methylbenzenesulfonohydrazide
-
Mus musculus
N'-(2-fluorobenzoyl)-4-methoxybenzenesulfonohydrazide
-
Mus musculus
N'-(2-methoxybenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-methylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(2-phenylisonicotinoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(piperazin-1-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(pyridin-3-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(pyrimidin-5-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(thiophen-2-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(thiophen-3-yl)benzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-acetylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-aminobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-chloro-2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-chloro-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-cyanobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-ethyl-2-fluorobenzoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(3-ethyl-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-fluorobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-isopropylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(3-methoxylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(4-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(4-cyanobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
-
Mus musculus
N'-(4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
-
Mus musculus
N'-(4-fluorobenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(4-methoxybenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(4-methylbenzoyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-(5-chloro-4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
-
Mus musculus
N'-(5-phenylnicotinoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(6-phenylpicolinoyl)benzenesulfonohydrazide
-
Mus musculus
N'-(naphthalen-2-ylsulfonyl)benzohydrazide
-
Mus musculus
N'-([1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
-
Mus musculus
N'-([1,1'-biphenyl]-3-carbonyl)naphthalene-2-sulfonohydrazide
-
Mus musculus
N'-benzoylbenzenesulfonohydrazide
-
Mus musculus
N'-[(3-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
-
Mus musculus
N'-[(3-ethylphenyl)sulfonyl]-2-fluorobenzohydrazide
-
Mus musculus
N'-[(4-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
-
Mus musculus
tert-butyl-(3-(2-(naphthalen-2-ylsulfono)hydrazinecarbonyl)-phenyl)carbamate
-
Mus musculus
WM-1119
-
Mus musculus
WM-8014 highly potent inhibitor, competitive inhibition with respect to acetyl-CoA Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BZ21
-
-

Synonyms

Synonyms Comment Organism
HAT
-
Mus musculus
KAT6A
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000002
-
pH and temperature not specified in the publication Mus musculus WM-1119
0.000008
-
pH and temperature not specified in the publication Mus musculus WM-8014
0.000008
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
0.00001
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(5-chloro-4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
0.000017
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-fluoro-[1,1'-biphenyl]-3-carbonyl)-benzenesulfonohydrazide
0.000043
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-chloro-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
0.000062
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-ethyl-2-fluorobenzoyl)naphthalene-2-sulfonohydrazide
0.000077
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
0.00012
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-3-methylbenzoyl)naphthalene-2-sulfonohydrazide
0.00013
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2,3-difluorobenzoyl)naphthalene-2-sulfonohydrazide
0.00013
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-chloro-2-fluorobenzoyl)benzenesulfonohydrazide
0.00016
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(thiophen-2-yl)benzoyl)benzenesulfonohydrazide
0.00023
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-3-methylbenzoyl)benzenesulfonohydrazide
0.00027
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-( 2-fluoro-[1,1'- biphenyl]-3-carbonyl)-benzenesulfonohydrazide
0.00029
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-([1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
0.00039
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-3-(trifluoromethyl)benzoyl)-benzenesulfonohydrazide
0.00046
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-[(4-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
0.00049
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.00049
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-3-methoxybenzoyl)benzenesulfonohydrazide
0.00052
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.00058
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-ethyl-2-fluorobenzoyl)benzenesulfonohydrazide
0.00062
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.00074
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2,3-difluorobenzoyl)benzenesulfonohydrazide
0.00079
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.00088
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-([1,1'-biphenyl]-3-carbonyl)naphthalene-2-sulfonohydrazide
0.00091
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluoro-5-methylbenzoyl)naphthalene-2-sulfonohydrazide
0.001
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-[(3-bromophenyl)sulfonyl]-2-fluorobenzohydrazide
0.001
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus CTX-0124143
0.0011
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluorobenzoyl)-3-methoxybenzenesulfonohydrazide
0.0013
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-fluoro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.0014
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-methyl-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.0017
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-chloro-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.0018
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-fluoro-N'-(phenylsulfonyl)benzohydrazide
0.0021
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-fluorobenzoyl)naphthalene-2-sulfonohydrazide
0.0028
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
0.0034
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.0035
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluorobenzoyl)-3-methylbenzenesulfonohydrazide
0.004
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.0041
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-fluoro-N'-[(3-fluorophenyl)sulfonyl]benzohydrazide
0.0042
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.0044
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-fluoro-N'-[[3-(trifluoromethyl)phenyl]sulfonyl]benzohydrazide
0.0057
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-fluoro-N'-[(3-fluorophenyl)sulfonyl]benzohydrazide
0.0062
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluorobenzoyl)-2-methylbenzenesulfonohydrazide
0.0067
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-benzoylbenzenesulfonohydrazide
0.0071
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2'-chloro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.0073
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.0074
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(piperazin-1-yl)benzoyl)benzenesulfonohydrazide
0.0078
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-isopropylbenzoyl)naphthalene-2-sulfonohydrazide
0.0082
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.009
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.0095
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.011
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3'-fluoro-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.011
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(trifluoromethyl)benzoyl)naphthalene-2-sulfonohydrazide
0.012
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-(2-(2-fluorobenzoyl)hydrazinylsulfono)benzamide
0.012
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus CTX-0124143
0.0125
-
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4-amino-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.0125
-
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.0125
-
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-dluorobenzoyl)-4-methylbenzenesulfonohydrazide
0.0125
-
IC50 above 0.0125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluorobenzoyl)-4-methoxybenzenesulfonohydrazide
0.013
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(thiophen-3-yl)benzoyl)benzenesulfonohydrazide
0.014
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 3-cyano-N'-(2-fluorobenzoyl)benzenesulfonohydrazide
0.017
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-fluorobenzoyl)-2-methoxybenzenesulfonohydrazide
0.018
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(6-phenylpicolinoyl)benzenesulfonohydrazide
0.018
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-methoxylbenzoyl)naphthalene-2-sulfonohydrazide
0.019
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-methylbenzoyl)naphthalene-2-sulfonohydrazide
0.019
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-phenylisonicotinoyl)benzenesulfonohydrazide
0.019
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-[(3-ethylphenyl)sulfonyl]-2-fluorobenzohydrazide
0.019
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-aminobenzoyl)naphthalene-2-sulfonohydrazide
0.022
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(5-phenylnicotinoyl)benzenesulfonohydrazide
0.024
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-cyanobenzoyl)naphthalene-2-sulfonohydrazide
0.0258
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4'-methoxy-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.029
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(pyrimidin-5-yl)benzoyl)benzenesulfonohydrazide
0.03
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.03
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-methylbenzoyl)naphthalene-2-sulfonohydrazide
0.041
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4'-cyano-N'-(phenylsulfonyl)biphenyl-3-carbohydrazide
0.042
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(2-methoxybenzoyl)naphthalene-2-sulfonohydrazide
0.049
-
in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-hydroxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.06
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.071
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus tert-butyl-(3-(2-(naphthalen-2-ylsulfono)hydrazinecarbonyl)-phenyl)carbamate
0.12
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-fluorobenzoyl)naphthalene-2-sulfonohydrazide
0.12
-
in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-methoxybenzoyl)naphthalene-2-sulfonohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(1H-pyrazol-1-yl)benzoyl)benzenesulfonohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.0004 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-(pyridin-3-yl)benzoyl)benzenesulfonohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 2-chloro-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus 4-butoxy-N'-(naphthalen-2-ylsulfonyl)benzohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(3-acetylbenzoyl)naphthalene-2-sulfonohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-(trifluoromethoxy)benzoyl)naphthalene-2-sulfonohydrazide
0.125
-
IC50 above 0.125 mM, in the presence of 0.015 mM acetyl-CoA, pH and temperature not specified in the publication Mus musculus N'-(4-cyanobenzoyl)naphthalene-2-sulfonohydrazide

General Information

General Information Comment Organism
malfunction enzyme inhibition induces cellular senescence Mus musculus