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Literature summary for 2.3.1.48 extracted from

  • Inagaki, Y.; Shiraki, K.; Sugimoto, K.; Yada, T.; Tameda, M.; Ogura, S.; Yamamoto, N.; Takei, Y.; Ito, M.
    Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity (2016), Int. J. Oncol., 48, 533-540 .
    View publication on PubMed
Search for more literature for 2.3.1.48

Inhibitors

Inhibitors Comment Organism Structure
C646 specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine Homo sapiens
-
 CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q09472
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
hepatoma HLE cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
SK-HEP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine
-
 Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
CBP/p300
-
 Homo sapiens
HAT
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme activity is upregulated in hepatocellular carcinoma compared to non-malignant liver tissues up