Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(3E,5E)-1-ethyl-3,5-bis[(4-hydroxy-3-nitrophenyl)methylidene]piperidin-4-one | 128% activity at 0.1 mM | Homo sapiens | |
(3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]piperidin-4-one | 114% activity at 0.1 mM | Homo sapiens | |
[(3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]-4-oxocyclohexyl]acetic acid | 128% activity at 0.1 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,6E)-2,6-bis[(3,4-dihydroxyphenyl)methylidene]cyclohexan-1-one | 89% residual activity at 0.1 mM | Homo sapiens | |
(2E,6E)-2,6-bis[(3,5-dibromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one | complete inhibition at 0.1 mM | Homo sapiens | |
(2E,6E)-2,6-bis[(3-fluoro-4-hydroxyphenyl)methylidene]cyclohexan-1-one | 6.3% residual activity at 0.1 mM | Homo sapiens | |
(2E,6E)-2,6-bis[(4-hydroxy-3-methylphenyl)methylidene]cyclohexan-1-one | 3.0% residual activity at 0.1 mM | Homo sapiens | |
(2E,6E)-2,6-bis[(4-hydroxyphenyl)methylidene]cyclohexan-1-one | 28.6% residual activity at 0.1 mM | Homo sapiens | |
(3E,5E)-1-benzyl-3,5-bis[(3,4-dihydroxyphenyl)methylidene]piperidin-4-one | 19.4% residual activity at 0.1 mM | Homo sapiens | |
(3E,5E)-3,5-bis[(3,4-dihydroxyphenyl)methylidene]-1-methylpiperidin-4-one | 82.4% residual activity at 0.1 mM | Homo sapiens | |
(3Z,5Z)-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]thian-4-one | 7.13% residual activity at 0.1 mM | Homo sapiens | |
1-benzyl-3,5-bis[(E)-3-bromo-4-hydroxybenzylidene]piperidin-4-one | 81.6% residual activity at 0.1 mM | Homo sapiens | |
2,5-bis[(E)-3-bromo-4-hydroxybenzylidene]cyclopentan-1-one | 41.2% residual activity at 0.1 mM | Homo sapiens | |
2,6-bis(3,4-dibromobenzylidene)cyclohexan-1-one | 85.1% residual activity at 0.1 mM | Homo sapiens | |
2,6-bis(3-bromo-4-hydroxybenzylidene)cyclohexanone | RC56, specific inhibitor, complete inhibition at 0.1 mM | Homo sapiens | |
2,6-bis(3-chloro-4-hydroxybenzylidene)cyclohexan-1-one | 7.7% residual activity at 0.1 mM | Homo sapiens | |
2,6-bis(3-chloro-5-fluoro-4-hydroxybenzylidene)cyclohexan-1-one | 41.1% residual activity at 0.1 mM | Homo sapiens | |
2,6-bis(4-hydroxy-3-iodobenzylidene)cyclohexan-1-one | 5.8% residual activity at 0.1 mM | Homo sapiens | |
2,6-bis[(6-hydroxy-1,1'-biphenyl-3-yl)methylene]cyclohexan-1-one | 92.2% residual activity at 0.1 mM | Homo sapiens | |
4,4'-(2-hydroxycyclohexane-1,3-diylidene)bis(methanylylidene)-bis(2-bromophenol) | 12.5% residual activity at 0.1 mM | Homo sapiens | |
5,5'-[(5-carboxy-2-oxocyclohexane-1,3-diylidene)bis(methanylylidene)]bis(2-hydroxybenzoic acid) | 70.1% residual activity at 0.1 mM | Homo sapiens | |
anacardic acid | - |
Homo sapiens | |
curcumin | - |
Homo sapiens | |
epigallocatechin-3-gallate | - |
Homo sapiens | |
garcinol | - |
Homo sapiens | |
Lys-CoA | - |
Homo sapiens | |
Plumbagin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [histone H3]-L-lysine20 | Homo sapiens | - |
CoA + [histone H3]-N6-acetyl-L-lysine20 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09472 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + [histone H3]-L-lysine20 | - |
Homo sapiens | CoA + [histone H3]-N6-acetyl-L-lysine20 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
p300 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0023 | - |
at pH 8.0 and 30°C | Homo sapiens | (2E,6E)-2,6-bis[(3,5-dibromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one | |
0.0081 | - |
at pH 8.0 and 30°C | Homo sapiens | 2,6-bis(4-hydroxy-3-iodobenzylidene)cyclohexan-1-one | |
0.0268 | - |
at pH 8.0 and 30°C | Homo sapiens | (2E,6E)-2,6-bis[(4-hydroxy-3-methylphenyl)methylidene]cyclohexan-1-one | |
0.0309 | - |
at pH 8.0 and 30°C | Homo sapiens | 2,6-bis(3-bromo-4-hydroxybenzylidene)cyclohexanone | |
0.035 | - |
at pH 8.0 and 30°C | Homo sapiens | (3Z,5Z)-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]thian-4-one | |
0.0389 | - |
at pH 8.0 and 30°C | Homo sapiens | (2E,6E)-2,6-bis[(3-fluoro-4-hydroxyphenyl)methylidene]cyclohexan-1-one | |
0.0455 | - |
at pH 8.0 and 30°C | Homo sapiens | 2,6-bis(3-chloro-4-hydroxybenzylidene)cyclohexan-1-one |