Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.48 extracted from

  • Fuellgrabe, J.; Lynch-Day, M.A.; Heldring, N.; Li, W.; Struijk, R.B.; Ma, Q.; Hermanson, O.; Rosenfeld, M.G.; Klionsky, D.J.; Joseph, B.
    The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy (2013), Nature, 500, 468-471.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H4 Homo sapiens acetylation of Lys16 CoA + acetylhistone H4
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H7Z6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
U-1810 cell
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4 acetylation of Lys16 Homo sapiens CoA + acetylhistone H4
-
?

Synonyms

Synonyms Comment Organism
histone H4 lysine 16 acetyltransferase
-
Homo sapiens
hMOF
-
Homo sapiens
KAT8
-
Homo sapiens
MYST1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

General Information

General Information Comment Organism
malfunction antagonizing H4K16ac downregulation upon autophagy induction results in the promotion of cell death Homo sapiens
metabolism alteration in the specific histone post-translational modification during autophagy affects the transcriptional regulation of autophagy-related genes and initiates a regulatory feedback loop,which serves as a key determinant of survival versus death responses upon autophagy induction Homo sapiens
physiological function autophagy is an evolutionarily conserved catabolic process involved in several physiological and pathological processes. Although primarily cytoprotective, autophagy can also contribute to cell death. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Induction of autophagy by rapamycin is coupled to reduction of histone H4 lysine 16 acetylation through downregulation of the histone acetyltransferase hMOF Homo sapiens