Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | Homo sapiens | acetylation of Lys16 | CoA + acetylhistone H4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H7Z6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
U-1810 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | acetylation of Lys16 | Homo sapiens | CoA + acetylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone H4 lysine 16 acetyltransferase | - |
Homo sapiens |
hMOF | - |
Homo sapiens |
KAT8 | - |
Homo sapiens |
MYST1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | antagonizing H4K16ac downregulation upon autophagy induction results in the promotion of cell death | Homo sapiens |
metabolism | alteration in the specific histone post-translational modification during autophagy affects the transcriptional regulation of autophagy-related genes and initiates a regulatory feedback loop,which serves as a key determinant of survival versus death responses upon autophagy induction | Homo sapiens |
physiological function | autophagy is an evolutionarily conserved catabolic process involved in several physiological and pathological processes. Although primarily cytoprotective, autophagy can also contribute to cell death. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Induction of autophagy by rapamycin is coupled to reduction of histone H4 lysine 16 acetylation through downregulation of the histone acetyltransferase hMOF | Homo sapiens |