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Literature summary for 2.3.1.48 extracted from

  • Simo-Riudalbas, L.; Perez-Salvia, M.; Setien, F.; Villanueva, A.; Moutinho, C.; Martinez-Cardus, A.; Moran, S.; Berdasco, M.; Gomez, A.; Vidal, E.; Soler, M.; Heyn, H.; Vaquero, A.; de la Torre, C.; Barcelo-Batllori, S.; Vidal, A.; Roz, L.; Pastorino, U.; Szakszon, K.; Borck, G.; Moura, C.S.; Carneiro, F.; Zondervan, I.; Savola, S.; Iwakawa, R.; Kohno, T.; Yokota, J.; Esteller, M.
    KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer (2015), Cancer Res., 75, 3936-3945.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene KAT6B, genotyping in small cell lung cancer cell lines, recombinant expression of GST- and FLAG-tagged KAT6B histone acetyltransferase domain in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information gene KAT6B mutational screening. shRNA-mediated depletion of KAT6B induces an increase in Rb phosphorylation, and KAT6B shRNA-depleted cells also show diminished expression of Brahma Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Homo sapiens acetylation of Lys23 CoA + acetylhistone H3
-
?
additional information Homo sapiens Brahma is a target of enzyme Kat6B ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WYB5
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST- and FLAG-tagged KAT6B histone acetyltransferase domain from Escherichia coli by affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
DMS-114 cell
-
Homo sapiens
-
NCI-H1048 cell
-
Homo sapiens
-
NCI-H1672 cell
-
Homo sapiens
-
NCI-H1963 cell
-
Homo sapiens
-
NCI-H2029 cell
-
Homo sapiens
-
NCI-H2171 cell
-
Homo sapiens
-
NCI-H740 cell
-
Homo sapiens
-
NCI-N417 cell
-
Homo sapiens
-
small cell lung cancer cell
-
Homo sapiens
-
WI-38 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 acetylation of Lys23 Homo sapiens CoA + acetylhistone H3
-
?
additional information Brahma is a target of enzyme Kat6B Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Homo sapiens
KAT6B
-
Homo sapiens
Morf
-
Homo sapiens
MYST4
-
Homo sapiens
tumor suppressor histone H3 lysine 23 acetyltransferase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the MYST family Homo sapiens
malfunction small cell lung cancer cells are deficient of the histone acetyltransferase KAT6B. The depletion of KAT6B expression enhances cancer growth, while its restoration induces tumor suppressor-like features. Enzyme deletion or inhibition confers sensitivity to irinotecan, causes diminished expression of Brahma, and induces an increase in Rb phosphorylation Homo sapiens
physiological function enzyme KAT6B has tumor suppressor–like properties in cancer cells and exerts its tumor-inhibitory role through a defined type of histone H3 Lys23 acetyltransferase activity Homo sapiens