Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine | i.e. BF1, shows substrate selectivity for histone H3 acetylation and inhibitory activity in vitro on recombinant HATs Gcn5 and p300. Both global acetylation of histone H3 and specific acetylation at lysine 18 (H3AcK18) are lowered by BF1 treatment | Homo sapiens | |
1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine | i.e. BF1, shows substrate selectivity for histone H3 acetylation and inhibitory activity in vitro on recombinant HATs Gcn5 and p300. Both global acetylation of histone H3 and specific acetylation at lysine 18 (H3AcK18) are lowered by BF1 treatment | Saccharomyces cerevisiae | |
additional information | synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors active both in vitro and in vivo, overview | Homo sapiens | |
additional information | synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors active both in vitro and in vivo, overview | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | Homo sapiens | - |
CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Saccharomyces cerevisiae | - |
CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H3 | Homo sapiens | acetylation at Lys18 | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | Saccharomyces cerevisiae | acetylation at Lys18 | CoA + acetylhistone H3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | from brain tumor | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
neuroblastoma cell | from neuronal tissue | Homo sapiens | - |
SK-N-BE(2) cell | - |
Homo sapiens | - |
U-87 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | - |
Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | - |
Saccharomyces cerevisiae | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H3 | acetylation at Lys18 | Homo sapiens | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | acetylation at Lys18 | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
HAT | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
evolution | acetyltransferases are very well conserved through evolution | Homo sapiens |
evolution | acetyltransferases are very well conserved through evolution | Saccharomyces cerevisiae |
metabolism | acetylation, which targets a broad range of histone and non-histone proteins, is a reversible mechanism and plays a critical role in eukaryotic genes activation/deactivation | Homo sapiens |
metabolism | acetylation, which targets a broad range of histone and non-histone proteins, is a reversible mechanism and plays a critical role in eukaryotic genes activation/deactivation | Saccharomyces cerevisiae |