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Literature summary for 2.3.1.48 extracted from

  • Kikuchi, H.; Nakayama, M.; Kuribayashi, F.; Mimuro, H.; Imajoh-Ohmi, S.; Nishitoh, H.; Nakayama, T.
    Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells (2015), Biochem. Biophys. Res. Commun., 467, 509-513.
    View publication on PubMed
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information generatiom of PCAF-deficient DT40 mutants, DELTAPCAF Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Gallus gallus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Gallus gallus acetylation at Lys9 CoA + acetylhistone H3
-
 ?
acetyl-CoA + histone H4 Gallus gallus acetylation at Lys14 CoA + acetylhistone H4
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DT-40 cell
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 acetylation at Lys9 Gallus gallus CoA + acetylhistone H3
-
 ?
acetyl-CoA + histone H4 acetylation at Lys14 Gallus gallus CoA + acetylhistone H4
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Gallus gallus
P300/CBP-associated factor
-
 Gallus gallus
PCAF
-
 Gallus gallus

General Information

General Information Comment Organism
evolution histone acetyltransferase p300/CBP-associated factor (PCAF) belongs to GCN5 family Gallus gallus
malfunction enzyme PCAF-deficiency causes drastic decrease in mRNA levels of Bcl-6 and Pax5, and remarkable increase in that of B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, PCAF-deficiency causes a remarkable decrease in acetylation levels of both H3K9 and H3K14 residues within chromatin surrounding the 5'-flanking regions of Bcl-6 and Pax5 genes in vivo Gallus gallus
metabolism enzyme PCAF is involved in transactivation of Bcl-6 and Pax5 genes, resulting in down-regulation of Blimp-1 gene expression, and plays a key role in epigenetic regulation of B cell development Gallus gallus
physiological function histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells. PCAF takes part in transcriptional activation of B cell lymphoma-6 (Bcl-6) and paired box gene 5 (Pax5), which are essential transcription factors for normal development of B cells. The enzyme regulates various epigenetic events for transcriptional regulation through alterations in the chromatin structure Gallus gallus